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. 2023 Feb 15;24(4):3929. doi: 10.3390/ijms24043929

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Representative image of diastereomeric peptides containing D-Amino acid in SARS-CoV-2 proteins and in toxin-like peptides in blood samples of infected individuals. Panel A: SACI-CIMS scan of voltages. Selective retention time ion cutting was employed; Panel B: Example of P0DTD1 protein (UniProt) in plasma of COVID-19 individuals. Replicase polyprotein 1ab; pp1ab; ORF1ab polyprotein. The rectangles show different retention scan times, suggestive of different D-Amino acids presence. Images of the spectra on the right side of panel B are highlighted at higher resolution in Figure S3 of supplementary materials. Panel C: different retention scan times of toxin-like peptides, D2DGD8 protein (UniProt): toxin-like peptides conotoxin. Panel D: different retention scan times of toxin-like peptide W8E7D1 protein (UniProt): toxin-like peptides phosphodiesterase.