Table 1.
Roles of the 18 identified candidates in different diseases/pathologies, as identified by Ingenuity Pathway Analysis (IPA). The table shows the name and number of the candidates from the list of 18 that participate in a given disease/pathology, the functional contribution, and the p-values of the association, based on the number of members of the comparison set for each disease set present in the database. Candidates are seen to play diverse roles, contributing to various processes in different functional capacities. All 18 candidates are implicated in cancer.
| Diseases/Pathology | Function | p-Value | Candidates | Number of Proteins (/18) |
|---|---|---|---|---|
| Cell Death and Survival | Apoptosis | 0.000115 | STAT4, DLL1, TLN1, IFNAR2, GFRA1, IL6R, CDC37, SH3RF1, AFP, RRM2B, USP53 | 11 |
| Cell Death and Survival, Organismal Injury and Abnormalities | Necrosis | 0.000173 | STAT4, DLL1, TLN1, IFNAR2, GFRA1, IL6R, CDC37, SH3RF1, AFP, RRM2B, USP53 | 11 |
| Cell-To-Cell Signalling and Interaction | Activation of lymphatic system cells | 0.000192 | DLL1, STAT4, TLN1, IL6R, AFP | 5 |
| Tissue Morphology | Quantity of cells | 0.000288 | STAT4, DLL1, TLN1, IFNAR2, GFRA1, IL6R, SHC2, AFP, KALRN | 9 |
| Cell Death and Survival, Organismal Injury and Abnormalities | Cell death of tumor cell lines | 0.000662 | DLL1, TLN1, IFNAR2, IL6R, CDC37, SH3RF1, AFP, RRM2B | 8 |
| Cell Death and Survival, Organismal Injury and Abnormalities | Cell death of immune cells | 0.000773 | DLL1, STAT4, TLN1, IL6R, AFP | 5 |
| Cellular Movement | Migration of cells | 0.0038 | DLL1, TLN1, GFRA1, IL6R, PARP9, SH3RF1, EPB41L5, KALRN | 8 |
| Nervous System Development and Function | Morphology of nervous system | 0.00591 | GFRA1, IL6R, SHC2, RRM2B, KALRN | 5 |
| Cell Morphology, Nervous System Development and Function, Tissue Morphology | Morphology of neurons | 0.00604 | GFRA1, IL6R, SHC2, KALRN | 4 |
| Neurological Disease, Organismal Injury and Abnormalities | Progressive neurological disorder | 0.0116 | DLL1, IFNAR2, IL6R, RRM2B, USP53 | 5 |
| Cancer, Organismal Injury and Abnormalities | Carcinoma | 0.0142 | STAT4, TLN1, IFNAR2, GFRA1, IL6R, SHC2, PARP9, EIF1AD, CDC37, SH3RF1, AFP, RRM2B, DLL1, EPB41L5, PSKH1, KALRN, GRB14, USP53 | 18 |