Table 1.
Melanoma tumor microenvironment characterization in the function of PD-L1 (+/-) expression.
| Nb. | Clinico- Pathological Aspects |
PD-L1 Expression in TILs | X2 Score |
p-Value | PD-L1 Expression in MTCs | X2 Score |
p-Value | ||
|---|---|---|---|---|---|---|---|---|---|
| Negative n (%) |
Positive n (%) |
Negative n (%) |
Positive n (%) |
||||||
| 1. |
Age <65 years >65 years |
8 (33.33%) 16 (66.67%) |
20 (54.05%) 17 (54.95%) |
2.517 |
0.126 |
17 (51.52%) 16 (48.48%) |
11 (39.29%) 17 (60.71%) |
0.912 |
0.243 |
| 2. |
Gender Males Females |
9 (37.50%) 15 (62.50%) |
22 (59.46%) 15 (40.54%) |
2.809 |
0.120 |
15 (45.45%) 18 (54.55%) |
16 (57.14%) 12 (42.86%) |
0.828 |
0.444 |
| 3. |
Localization Acral Upper body Cervico-cranial Limbs |
3 (12.5%) 7 (29.17%) 9 (37.5% 5 (20.83%) |
2 (5.41%) 19 (51.35%) 3 (8.11%) 13 (35.14%) |
9.603 * |
0.018 |
3 (9.1%) 11 (33.33%) 7 (21.2%) 12 (36.36%) |
2 (7.1%) 15 (53.62%) 5 (17.86%) 6 (21.43%) |
2.791 |
0.443 |
| 4. |
Clark level of invasion I II III IV V |
6 (25%) 2 (8.33%) 4(16.67%) 11(45.83%) 1(4.17%) |
3 (8.11%) 4 (10.81%) 6(16.22%) 21 (56.76%) 3 (8.11%) |
3.584 |
0.494 |
7 (21.22%) 1 (3.03%) 3 (9.09%) 19 (57.58%) 3 (9.09%) |
2(7.14%) 5 (17.86%) 7 (25.00%) 13 (46.43%) 1 (3.57%) |
8.819 |
0.068 |
| 5. |
Breslow tumor thickness <1 mm 1–2 mm 2–4 mm >4 mm |
4 (16.67%) 0 (0%) 3 (12.50%) 17 (70.83%) |
2 (5.41%) 3 (8.11%) 12 (32.43%) 20 (54.05%) |
6.851 |
0.086 |
6 (18.18%) 0 (0%) 6 (18.18%) 21 (63.64%) |
0 (0%) 3 (10.71%) 9 (32.14%) 16 (57.14%) |
9.933 * |
0.014 |
| 6. |
Lymphovascular invasion Present Absent |
10 (41.67%) 14(52.14%) |
24 (64.86%) 13(35.14%) |
3.175 |
0.113 |
16 (48.48%) 17 (51.52%) |
18 (64.29%) 10 (35.71%) |
1.533 |
0.216 |
| 7. |
Perineural invasion Present Absent |
5 (20.83%) 19 (79.17%) |
9 (14.75%) 33 (89.19) |
1.163 |
0.298 |
5 (15.15%) 28 (84.85%) |
4 (14.29%) 24 (85.71%) |
0.009 |
0.926 |
PD-L1- Programmed cell death ligand-1; TILs-tumor-infiltrating lymphocytes; MTCs-melanoma tumor cells; * p < 0.05 represents statistically significant differences between cases made by Pearson Chi-Square with Cramer’s V test for the association between categorical variables, Mann-Whitney U Test and Kruskal-Wallis H Test for Continuous variables (X2 Score).