Table 3.
Receiver operating characteristic (ROC) analysis of PD-L1, CD4, and CD8 tumor-infiltrating lymphocyte biomarkers in melanoma patients.
| Nb. | Biomarkers | AUC | 95% CI * | p-Value | Youden J Index |
Cut-Off Value | Sensitivity | Specificity |
|---|---|---|---|---|---|---|---|---|
| 1. | PD-L1 TILs | 0.959 | 0.875 to 0.993 | <0.001 | 0.889 | >3 | 97.30 | 91.67 |
| 2. | PD-L1 M | 0.975 | 0.898 to 0.998 | <0.001 | 0.934 | >0 | 96.43 | 96.97 |
| 3. | CD4 M | 0.950 | 0.862 to 0.989 | <0.001 | 0.743 | >15 | 84.31 | 90.00 |
| 4. | CD8 M | 0.941 | 0.850 to 0.985 | <0.001 | 0.758 | >10 | 89.13 | 86.67 |
UC = area under the curve; ROC = receiver operating characteristic; * Confidence interval; Youden J = sensitivity + specificity – 100; PD-L1- Programmed cell death ligand-1; TILs- tumor-infiltrating lymphocytes; M- melanoma tumor cells.