Table 1.
The influence of Piezo activation on different cancer cells.
| Cancer | Protumorigenic Effect | Antitumorigenic Effect | Additional Information |
|---|---|---|---|
| Breast cancer | Invasion, confined migration, proliferation [1,64,66] | Unconfined migration, proliferation [64,66] | |
| Oral cancer | Proliferation [67,68,69,70,71,72,73,74,75] | ||
| Laryngeal cancer | Migration [76] | ||
| Gastric cancer | Invasion, migration, proliferation, angiogenesis [77,78,79,80,81,82] | ||
| Bladder cancer | Invasion, proliferation, migration [48,84,85] | ||
| Lung cancer | Higher overall survival rate [88] | Piezo inhibition supports tumor migration [87,88,89,90,91,92,93,94] | |
| Leukemia | Maintaining volume homeostasis in erythrocytes [93,94,95,96] | ||
| Glioma | Proliferation, metastasis, angiogenesis, extracellular matrix reorganization [100,101] |
The correlation between Piezo1 overexpression and peritumoral brain edema [100] | |
| Esophageal Squamous Cell Carcinoma | Invasion, migration [98] |
Piezo1 expression is linked with the TP53 pathway [98] | |
| Prostate cancer | Proliferation, migration, tumor growth [105] |
Piezo1 overexpression causes activation of the Akt/mTOR pathway [105] | |
| Colon cancer | Migration, metastasis, vascular invasion [108,116] | The connection between Piezo1 and MCU, HIF-1a and VEGF [109,110] | |
| Osteosarcoma | Apoptosis reduction, invasion [111] |
||
| Synovial sarcoma | Increasing cancer cell viability [112] |