Table 1.

Description of BNT162b modRNA vaccine candidates.

BNT162 Vaccine Candidate (Product Code)	SARS-CoV-2 Variant a	Encoded Antigen	Sequence Variant b
BNT162b1	Wild type	SARS-CoV-2 RBD, a secreted variant	V5
BNT162b2	Wild type	Full-length SARS-CoV-2 S protein bearing mutations preserving neutralization-sensitive sites	V8 and V9 c
BNT162b3	Wild type	SARS-CoV-2 RBD, a membrane-bound variant	V5TM

^a Wild type refers to the USA-WA1/2020 strain. ^b Sequence variant refers to the nucleotide sequence of the RNA component encoding the antigen. ^c Note that there were two variants of the BNT162b2 vaccine tested. The RNA component of the two sequence variants (V8 and V9) have different nucleotide sequences, but both encode the same antigen. Abbreviations: RBD = receptor binding domain; S protein = spike protein; V = variant.