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. 2023 Feb 16;15(2):669. doi: 10.3390/pharmaceutics15020669

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Scheme 2 — Synthesis of N¹,N¹²-bis(7-chloroquinolin-4-yl)dodecane-1,12-diamine (12). Reagents and conditions: (i) dodecane-1,12-diamine (0.5 equiv.), NaI (10% w/w), phenol (5 equiv.), MW (150 W; 150 °C), 30 min.