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. 2023 Feb 4;24(4):3060. doi: 10.3390/ijms24043060

Figure 4.

Figure 4

Effects of picrocrocin on the transcription of genes related to lipid metabolism. (A) qPCR analysis of the mRNA levels for the main proteins involved in lipid homeostasis after treatment of HepG2 for 24 and 48 h with PEF from our saffron extract (300 µg/mL). (B) qPCR analysis of mRNA levels after treatment of HepG2 cells for 24 and 48 h with pravastatin (5 µM). These results highlight PEF’s ability to modulate the mRNA levels of proteins involved in lipogenesis with a method different from that of pravastatin. Values represent mean ± SD of three independent experiments. * p value < 0.05; ** p value < 0.01; *** p value < 0.001; ns: non-significant.