Table 7.
Haematological and biochemical markers in the pessary and standard group.
| Variables | Period | Pessary Group (n = 33) | Standard Group (n = 33) | p-Value |
|---|---|---|---|---|
| Random Blood Sugar (mg %) | Day 0 | 99.76 ± 12.97 | 99.88 ± 14.74 | 0.972 |
| Erythrocyte Sedimentation Rate (mm/1 h) | Day 0 | 35.85 ± 13.54 | 33.70 ± 14.59 | 0.537 |
| Day 14 | 30.91 ± 10.09 a | 35.36 ± 14.37 b | 0.15 | |
| Safety biomarkers | ||||
| Haemoglobin (Hb%) (gm%) | Day 0 | 11.35 ± 1.48 | 11.21 ± 1.15 | 0.665 |
| Day 14 | 11.17 ± 1.33 a | 11.26 ± 1.09 b | 0.779 | |
| Total Leucocyte Counts (cells/cumm) | Day 0 | 6515.15 ± 1439.21 | 6112.12 ± 1437.83 | 0.259 |
| Day 14 | 6309.09 ± 1673.20 a | 5975.75 ± 1267.4 b | 0.365 | |
| Aspartate aminotransferase (IU/L) | Day 0 | 22.28 ± 7.32 | 22.31 ± 9.52 | 0.988 |
| Day 14 | 21.33 ± 6.76 a | 22.24 ± 9.10 b | 0.647 | |
| Alanine transaminase (IU/L) | Day 0 | 24.62 ± 11.47 | 23.79 ± 11.3 | 0.769 |
| Day 14 | 23.76 ± 9.22 a | 24.97 ± 12.61 b | 0.657 | |
| Alkaline phosphatase (IU/L) | Day 0 | 199.60 ± 55.35 | 207.18 ± 42.04 | 0.533 |
| Day 14 | 204.52 ± 39.59 a | 202.27 ± 41.91 b | 0.824 | |
| Blood Urea (mg %) | Day 0 | 22.64 ± 5.63 | 23.12 ± 3.85 | 0.686 |
| Day 14 | 24.45 ± 3.59 a | 23.70 ± 4.21 b | 0.434 | |
| Serum Creatinine (mg %) | Day 0 | 0.76 ± 0.09 | 0.78 ± 0.10 | 0.52 |
| Day 14 | 0.76 ± 0.09 a | 0.75 ± 0.08 b | 0.579 | |
| Other investigations | ||||
| C-Reactive Protein | ||||
| Positive | Day 0 | 10 (100) | 8 (100) | 0.78 |
| Negative | Day 14 | 5 (50) | 5 (62.5) | 1.00 |
| Ultrasonography of abdomen | ||||
| Normal | - | 16 (48.5) | 21 (63.6) | 0.32 |
| PID | 17 (48.5) | 12 (36.4) | ||
| PH of vaginal discharge | Day 0 | 5.21 ± 1.05 | 4.70 ± 1.69 | 0.145 |
| Day 14 | 4.42 ± 0.71 | 3.48 ± 1.44 | 0.016 | |
| p value | 0.007 | 0.03 | ||
| Pap smear | ||||
| Normal | 6 (18.2) | 6 (18.2) | ||
| Inflammatory | Day 0 | 21 (63.6) | 24 (72.7) | 0.548 |
| Bacterial Vaginosis | 6 (18.2) | 3 (9.1) | ||
| Normal | 22 (66.7) | 10 (30.3) | ||
| Inflammatory | Day 14 | 11 (33.33) | 22 (66.7) | 0.003 |
| Bacterial Vaginosis | (0) | 1 (3) | ||
| p value | p < 0.001 | 0.365 | ||
Fisher’s exact test; a p > 0.05 and b p > 0.05 on day 14 from day 0 in the pessary and standard group respectively.