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. 2023 Feb 17;11(2):189. doi: 10.3390/toxics11020189

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Protein targets were identified by the 2D PISA method for TCDD and the soluble proteome from hepatocytes. The studied concentrations were 100, 90, 80, 70, 60, 50, 40, 30, 20, and 0% (concentrations from 20 to 90% were pooled for the MS/MS analysis and the obtained data were used to calculate F_c while data from 100% concentration were used to calculate F_t). The highest concentration (100%) corresponds to 25 nM TCDD. Identified protein targets are shown in red and labeled. Significant proteins for F_t or F_c are shown in blue. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article).