Table 2.
Summary of quantitative measures of model performance for ketoconazole and its metabolite M1.
| Compound (n) | Mean MRD | Mean GMFE AUClast | Mean GMFE Cmax |
|---|---|---|---|
| Ketoconazole (52) | 1.42 | 1.37 | 1.24 |
| M1 (1) | 2.51 | 1.48 | 2.15 |
| Overall | 1.45 | 1.37 | 1.26 |
| Profiles with measure ≤ 2 | 49/53 | 50/53 | 52/53 |
| Range | 1.09–2.69 | 1.00–2.57 | 1.00–2.15 |
AUClast: area under the plasma concentration-time curve from the time of drug administration to the time of the last concentration measurement; Cmax: maximum plasma concentration; GMFE: geometric mean fold error; M1: N-deacetylketoconazole; MRD: mean relative deviation; n: number of mean plasma concentration-time profiles.