Figure 2.

(a) Hemispheric area loss (%). P7 rat pups underwent ligation of the left carotid artery followed by 90 min of hypoxia. Pups were randomized to either 5 h of NT (37 °C) or 5 h of TH (32 °C) after hypoxia and were sacrificed after 7 days of survival. Therapeutic hypothermia significantly reduced brain area loss. (b,c) Representative image of coronal section from NT brain (b) and TH brain (c) staining with eosin showing the damage over the ipsilateral side on the NT treatment compared to TH treatment. n = 21 animals (n = 10 NT and n = 11 for the TH group). Student’s t-test was performed with a * p < 0.05. Data are expressed as median (interquartile range).