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Schematic illustration of the molecular mechanisms which can be targeted to increase SLC drug transporter expression on cell plasma membrane. Nucleus receptor (1), DNA de-methylation (2) and histone de-acetylation (3) mediated increase in transporter expression. Ubiquitination inhibition mediated reduction of transporter recycling from the plasma membrane (4). Inhibition of Protein kinases C (PKCs) mediated internalization of transporters from plasma membrane (5).
