Table 2.
Examples of natural polymer-based drug delivery systems.
| Hydrogel Source | Additional Components |
Synthesis Method |
Loaded Drug | Reference |
|---|---|---|---|---|
| Chitosan | --- | Formaldehyde crosslinking |
DOX/5-FU | [47] |
| Sodium alginate |
--- | Ionic crosslinking | S-nitrosoglutathione | [48] |
| Sodium alginate |
Polyvinyl alcohol/ benzeneboronic acid |
Ionic crosslinking | Proteins | [49] |
| Sodium alginate |
--- | Ionic crosslinking | Iohexol | [50] |
| Sodium alginate |
Polyvinyl pyrrolidone | Ionic crosslinking | Exosomes | [51] |
| Sodium alginate |
Chitin nanowhiskers | Ionic crosslinking | Metronidazole | [52] |
| Hyaluronic acid | Gelatin | UV radiation | Epigallocatechin- 3-gallate |
[53] |
| Hyaluronic acid | Core–shell SiO2
nanoparticles |
UV radiation | Doxorubicin/ glucose oxidase |
[54] |
| CMC | HKUST-1 | Ionic crosslinking | Baclofen | [55] |
| HPMC | SiO2/Glycerol | Chemical crosslinking | Serpin B3 | [56] |
| HPMC | Carbopol 971p | Chemical crosslinking | Atenolol | [57] |
| HPMC | Pluronic F127 (PF127) and F68 (PF68) | Temperature-dependent gelation | Primaquine | [58] |
| κ-carrageenan | --- | Freeze-drying process | Metformin | [59] |
| ι-carrageenan | β-cyclodextrins | Maturation | Methotrexate | [60] |