Table 5.
Limits of detection (LODs) and limits of quantification (LOQs) for lyso-Gb3 and its analogues in dried blood spots (DBSs).
| LOD | LOQ | |||||
|---|---|---|---|---|---|---|
| Whatman-GE 903 | Capitainer®B | Plasma | Whatman-GE 903 | Capitainer®B | Plasma | |
| nM | nM | nM | nM | nM | nM | |
| Lyso-Gb3-13C6 | 0.21 | 0.40 | na | 0.70 | 1.34 | na |
| Lyso-Gb3 | 0.32 | 0.37 | 0.23 | 1.08 | 1.23 | 0.77 |
| Lyso-Gb3 (Analogue − 28 Da) | 0.11 | 0.18 | 0.06 | 0.36 | 0.59 | 0.21 |
| Lyso-Gb3 (Analogue −2 Da) | 0.22 | 0.15 | 0.29 | 0.73 | 0.55 | 0.97 |
| Lyso-Gb3 (Analogue +16 Da) | 0.10 | 0.39 | 0.22 | 0.32 | 1.29 | 0.72 |
| Lyso-Gb3 (Analogue +18 Da) | 0.13 | 0.23 | 0.14 | 0.42 | 0.77 | 0.47 |
| Lyso-Gb3 (Analogue +34 Da) | 0.13 | 0.19 | 0.24 | 0.43 | 0.64 | 0.79 |
LOD = limit of detection; LOQ = limit of quantification; na = not applicable.