Table 1.

Differential diagnosis of Gianotti–Crosti-like eruptions.

Differential Points	Gianotti–Crosti-Like Eruptions	Gianotti–Crosti Eruptions	Papulosquamous Urticaria	Erythema Infectiosum
Fever	More fever.	Low fever.	Generally no fever.	Fever.
Skin rash	Papules are symmetrically distributed on the face, arms and legs but relatively sparse on the trunk. Stomatitis of the oral mucosa [9,15].	Monomorphous, flat-topped, firm papules or papulovesicles. Located on the face, extensor surfaces of the extremities and buttocks. Symmetrical distribution. Lesions usually do not involve the palms, soles or mucous membranes of the hands [13].	Multiple bites and local pruritus. Grouped or disseminated urticarial papules, vesicles or wheals. Scratching can lead to ulcers and erosions.	The prodromal symptoms are low fever, malaise, sore throat, headache and nausea; after a few days, a red “slap on the cheek” facial rash appears. After two to four days, the facial rash subsides. Pink patches and blotches may appear in a lacy web-like pattern, most commonly on the extremities [16].
Itching	Mostly with pain and itching.	Mild to moderate itching.	Intense itching, possible epidermal peeling.	Paroxysmal itching, mostly worse at night.
Blisters	Mostly vesicles, blisters and large blisters.	Rarely seen.	Small blisters often present and can develop into large blisters.	Not yet been reported.
Recurrence	Presence of secondary features, peeling nails and peeling skin on hands and feet.	Rare recurrence.	Chronic or recurrent.	Disappears and reappears intermittently and disappears after a few days or weeks.
Duration	Usually one week.	Lasts significantly longer (2–8 weeks).	Can last from 2 to 12 days.	Around 1–6 weeks.
Pathogens	CVA6.	Epstein–Barr virus and hepatitis B virus Other viral factors such as CVA16, CVB4, CVB5, parvovirus B19, etc.	Often occurs after bites of insects such as mosquitoes, sandflies, bed bugs and fleas [17,18].	Caused by microvirus infection.
Prevalence age	Commonly seen in children and adolescents.	Commonly seen in children aged 1 to 6 years.	Commonly seen in children.	Usually involves children aged 3 to 12 years [19].