Table 2.

Differential diagnosis of eczema coxsackium.

Differential Points	Eczema Coxsackium	Herpes Zoster	Herpetic Eczema
Fever	Usually accompanied by fever symptoms.	Fever is common.	Usually accompanied by fever.
Skin rash	Blisters and vesicles within the original dermatitis. The lesions are most severe in areas of eczema on bends, such as those on the arms and legs.	A characteristic narrow band-like rash on one side of the body from the spine to the front of the trunk. It may also occur on the face, eyes, mouth and ears. Mainly with skin inflammation and blisters [25].	Monomorphic eruptions of dome-shaped papulovesicles. After 1 or 2 weeks, blisters dry and form crusts that fill eroded pits. Vesicles may also be umbilicated, and the presence of ulcerations or slits is possible. Lesions are completely dried and healed after 2 to 6 weeks [26].
Pain or itching	Papules and blisters are mostly painful [27].	Severe and disabling pain.	Skin injuries are mostly painful.
Complications	Spontaneous regression and no serious systemic complications.	Postherpetic neuralgia, which is characterized by severe pain.	Including viremia, meningitis or encephalitis, hepatitis and septicemia due to Staphylococcus aureus infection.
Recurrence	In most patients, the rash shows signs of secondary bacterial infection.	Immunity develops after having shingles, and recurrences are uncommon in immunocompetent people.	Generally, no recurrence.
Duration	Lasts approximately 7–10 days.	Lasts approximately 2–4 weeks.	Lasts approximately 2–6 weeks.
Pathogens	Mostly CVA6.	Varicella zoster virus.	Herpes simplex virus.
Prevalence age	Commonly seen in children and adolescents.	Anyone infected with the primary varicella zoster virus can develop shingles.	Prevalent in children.