Figure 2.

Schematic representation of multiple genes and their association with neuropathological events in AD. The four classical genes associated with familial AD are in the blue box, whereas other novel genes related to sporadic AD are in the red boxes. Word color-coding: red: increased production/aggregation of Aβ or tau; green: alteration in the clearance of Aβ or tau; blue: Aβ- or tau-mediated neuronal damage; purple: Tau phosphorylation. Furthermore, the respective associations with neuropathological mechanisms are indicated in yellow boxes. Abbreviations: AICD: amyloid precursor protein intracellular domain; APP: amyloid precursor protein; BACE1: β secretase; BBB: blood–brain barrier; CTF: C-terminal fragment; sAPP-β: soluble amyloid precursor protein β. This figure was created with biorender.com.