Figure 2.

Non-Amyloidogenic and Amyloidogenic pathways of APP. In the non-amyloidogenic pathway, α-secretase cleavage of the Aβ region produces sAPPα and C83 fragments, and then γ-secretase cleavage of C83 produces p3 and AICD fragments which precludes Aβ formation. In the amyloidogenic pathway, cleavage of the Aβ region produces sAPPβ and C99 fragments. Then, the C99 fragment is cleaved by the γ-secretase complex into Aβ and AICD fragments. Accumulation of Aβs in the tissue forms plaque.