Table 1.
Relationship between Graves’ disease and level of vitamin D.
| Study | Year | Case Group (F/M) |
Control Group (F/M) |
Age of Case Group | Age of Control Group | Level of Vitamin D Case |
Level of Vitamin D Control |
Level of TRAb (IU/l) |
Association |
|---|---|---|---|---|---|---|---|---|---|
| Bouillon et al. [72] | 1980 | 77/27 | - | 39 | - | 28 ± 11 (ng/L) |
42 ± 13 (ng/L) |
- | + |
| Yasuda et al. [70] | 2012 | 26/0 | 46/0 | 37.3 ± 13.0 | 44.3 ± 18.1 | 14.4 ± 4.9 (ng/mL) |
17.1 ± 4.1 (ng/mL) |
19.9 ± 18.1 | + |
| Jyotsna et al. [75] | 2012 | 62/18 | 62/18 | 36.33 ± 11.15 | 36.42 ± 10.40 | 12.67 ± 6.24 (ng/mL) |
10.99 ± 7.05 (ng/mL) |
- | - |
| Unal et al. [45] | 2014 | 27 (F&M) |
124 (F&M) |
44.6 | 44.6 | 14.9 (4–39) (ng/mL) |
19.9 (9–122.7) (ng/mL) |
- | + |
| Ma et al. [71] | 2015 | 70 (F&M) |
70 (F&M) |
40.04 ± 15.24 | 41.99 ± 13.31 | 31.71 ± 13.10 (nmol/L) |
41.33 ± 14.48 (nmol/L) |
14.16 (5.81–27.92) |
+ |
| Kim et al. [52] | 2016 | 148 (F&M) |
407 (F&M) |
- | 48.6 ± 13.3 | 39.3 ± 22.0 (ng/mL) |
39.9 ± 21.5 (ng/mL) |
- | - |
| Ke et al. [53] | 2017 | 30/21 | 31/20 | 39.79 ± 1.73 | 36.48 ± 1.68 | 81.77 ± 5.60 (nmol/L) |
83.49 ± 6.24 (nmol/L) |
- | - |
| Planck et al. [76] | 2018 | 246/46 | 921/1384 | 45.5 ± 13.1 | 59.4 ± 7.2 | 55.0 ± 23.2 (nmol/L) |
87.2 ± 27.6 (nmol/L) |
- | + |
| Mangaraj et al. [69] | 2019 | 54/30 | 25/17 | 35.25 ± 9.70 | 32.41 ± 9.71 | 19.22 ± 8.95 (ng/mL) |
23.81 ± 12.46 (ng/mL) |
19.45 ± 12.12 | + |