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A model describing the involvement of ATP1A1 in PEDV attachment. ATP1A1 plays an important role as a host factor that facilitates PEDV attachment. Overall, ATP1A1 is involved in recognition of hosts together with unknown functional receptors. ATP1A1 mAb interferes with the recognition of ATP1A1 and PEDV on the cell surface and inhibits viral infection. ATP1A1-specific inhibitors treatment leads to partial internalization and degradation of ATP1A1, reducing viral recognition.
