Table 1.

Gene expression profiles involved in AD in HFD/Lean, HFD-H/HFD, HFD-L/HFD and HFD-H + L/HFD, which were significantly downregulated by 2-fold.

Gene Name	Protein	HFD/Lean	HFD-H/HFD	HFD-L/HFD	HFD-H + L/HFD
Ache	Acetylcholinesterase	2.10	−30.84	−12.01	−16.31
Apba3	Amyloid beta (A4) precursor protein-binding, family A, member 3	44.94	−59.17	−30.02	−29.88
Apbb2	Amyloid beta (A4) precursor protein-binding, family B, member 2	2.60	−18.46	−10.71	−17.39
Aplp1	Amyloid beta (A4) precursor-like protein 1	5.17	−8.79	−8.53	−5.00
Aplp2	Amyloid beta (A4) precursor-like protein 2	15.97	−45.55	−15.49	−17.72
Apoe	Apolipoprotein E	5.16	−26.20	−9.36	−9.77
App	Amyloid beta (A4) precursor protein	6.05	−15.85	−9.94	−10.12
Bdnf	Brain derived neurotrophic factor	−17.99	−5.49	−3.44	−2.67
Cdk5	Cyclin-dependent kinase 5	2.92	−36.93	−17.68	−13.99
Clu	Clusterin	26.50	−4.04	−3.76	−2.19
Ctsl	Cathepsin L	5.08	−13.34	−4.65	−4.90
Gsk3 a	Glycogen synthase kinase 3 α	7.20	−22.22	−14.11	−15.35
Hsd17b10	Hydroxy steroid deydrogenase10	5.87	−15.93	−9.38	−11.82
Il1a	Interleukin 1 α	4.31	−90.55	−49.60	−98.59
Mapt	Microtubule-associated protein tau	44.58	−23.78	−9.87	−8.28
Mpo	Myeloperoxidase	14.87	−33.10	−14.25	−28.87
Prkca	Protein kinase C, alpha	6.17	−16.16	−15.98	−10.33
Prkce	Protein kinase C, epsilon	5.89	−16.58	−12.56	−16.61
Psen1	Presenilin 1	4.68	−225.85	−152.13	−193.57