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. 2023 Feb 6;24(4):3183. doi: 10.3390/ijms24043183

Figure 1.

Figure 1

Engineering of LNOC. Schematic of the human native lymph node (a) and LNOC structure (b), reproducing structural features of LN with secondary tumor. 1—suction cup; 2—main channel; 3—cellular spheroid; 4—chip body. Cells stained in blue—secondary tumor cells, green—lymphocyte; red—capsules. (c) Secondary tumor due to metastasis in the sentinel lymph node (keratin stain). Reprinted with permission from Elizabeth Euscher (2020) [38]. (d) Photo of chip installed in the Operetta CLM system. (e) Macrophotograph of the assembled and ready to use chip.