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The latent infection of HSV-1 leads to permanent arrest in an G0/G1-like state in the sensory ganglia that will never reenter mitosis ①. During reactivation, virus genes are expressed in cells in the most permissive state ②. Then, reactivated virions travels in axons ③ to termini on the epidermis ④, and then transmitted to the spinosum and granulosum strata layers of the epidermis ⑤ [17].
