Figure 1.

Neutralization of WNV by serum from HBcAg-wDIII VLP immunized mice. The neutralization potency against WNV of pooled sera from mice that were immunized with HBcAg-wDIII VLP (VLP) or mock-immunized with PBS collected at 5 week post-immunization was measured by a PRNT assay. Sera were diluted 100-fold and incubated with 10² PFU of WNV prior to Vero cell infection. Mean % neutralization and SD from two independent experiments with technical triplicates for each sample are presented. − Control: PBS buffer in the PRNT assay. **** indicates p values < 0.0001 of HBcAg-wDIII VLP-immunized sera compared to sera from PBS-inoculated mice.