Figure 3.

Protection of recipient mice from WNV infection by serum of HBcAg-wDIII VLP immunized mice. BALB/c mice were passively administered (r.o.) with 50 µL of heat inactivated serum collected from mice that were immunized with HBcAg-wDIII VLP (wDIII VLP) or mock-immunized with PBS. In the positive control group, 10 µg of a protective mAb was administered in place of serum. Mice were challenged with 10² PFU of WNV 1 h after receiving serum or mAb. Two independent experiments with n = 10 mice per treatment were performed. The p-value (p = 0.0004) for HBcAg-wDIII VLP-immunized mice (compared to PBS-mock immunized) is presented.