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. 2023 Jan 17;11(2):197. doi: 10.3390/vaccines11020197

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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ADE activity of anti- HBcAg-wDIII VLP serum for ZIKV and DENV infection. Total serum IgG was isolated from pooled sera collected at week 11 from PBS or HBcAg-wDIII VLP- (VLP) vaccinated mice. IgGs were serially diluted, mixed with ZIKV (A) or DENV-2 (B), and incubated with FcγR-expressing K562 cells. After incubation of 72 h for ZIKV or 48 h for DENV-2, ZIKV- or DENV-2-infected cells were detected by flow cytometry. A known ADE-causing anti-flavivirus E mAb (4G2) was used as the ADE positive control (A,B). Enhancement of ZIKV or DENV infection by serum antibodies is presented as a % relative to the positive control, mAb 4G2.