Table 4.

IC50 and SI values of tested thiadiazoles (C1 and NTBD); *—MIC of thiadiazole derivatives alone; **—range of thiadiazole derivatives MIC values in the combination with AmB, which exhibited a synergistic effect with the antibiotic.

Drug	IC50 RPTECs (μg/mL)	Strain	Drug Concentration (μg/mL)	Selectivity Index (μg/mL)
C1	161.4 ± 4.0	C. albicans	128 *	1.26
			4–32 **	40.35–5.04
		C. parasitosis	64 *	2.51
			4–16 **	40.35–10.09
NTBD	18.82 ± 5.0	C. albicans	256 *	0.07
			16 **	1.18
		C. parapsilosis	256 *	0.07
			4–64 **	4.71–0.29