Figure 1.

Anlotinib improved albuminuria and serum creatinine in an FA-induced mouse model. FA-induced mouse models of nephropathy were treated with or without anlotinib in this study. (a) Intervention dosing regimen of folic acid in an experimental mouse model of kidney fibrosis. (b) 24-hour urinary albumin excretion and serum creatinine were measured at 14 days after folic acid injection, and both were significantly increased and later reduced after the mice were treated with anlotinib in FA-induced mice compared to the control group. (c) Established UUO-induced mouse models of kidney fibrosis. (d) UUO-induced mouse models of nephropathy showed no significance when treated with or without anlotinib in 24-hour urinary albumin excretion and serum creatinine. Results are presented as mean ± SEM. ^∗∗P < 0.01, n.s indicates not significant (P > 0.05), n = 3.