Table 2.
Bivariate analysis between subjects with and without thrombosis.
| Thrombosis n = 60 * |
No Thrombosis n = 239 |
|||
|---|---|---|---|---|
| Median (IQR) | Median (IQR) | Median Difference (95% CI) | p-Value | |
| Age, years | 60 (51–65.9) | 63.2 (53–72) | −2.3 (−5.5–0.95) | 0.043 |
| Blood test results | ||||
| D-dimer | 1859.5 (1151–5970) | 1605 (772–3335) | 280 (−2039.3–2600.8) | 0.786 |
| Fibrinogen | 813 (567–1020) | 781 (625–903) | 27.2 (−38.1–92.6) | 0.410 |
| Leucocytes | 7.85 (5.2–12.1) | 7.30 (5.32–10.3) | 0.39 (−1.50–0.79) | 0.527 |
| Lymphocytes | 0.77 (0.47–1.2) | 0.70(0.40–1.0) | −0.02 (−0.17–0.10) | 0.511 |
| Platelets | 239 (173–283) | 210 (160–274) | 2.6 (−24.9–30.21) | 0.851 |
| Ferritin | 1006.5 (528–1573.2) | 925.4 (474–1634) | 138.5 (−624.6–901.8) | 0.721 |
| C-reactive protein | 120.1 (64.7–277.4) | 128.7 (82.4–206.7) | 7.32 (−26.5–41.1) | 0.668 |
| Prothrombin time | 13.1 (12–16.1) | 13.4 (11.9–58) | 3.5 (−10.9–3.07) | 0.268 |
| IL6 | 95.2 (42–238.2) | 71.1 (38–167.8) | 10.5 (−73.3–94.4) | 0.803 |
| Creatinine | 0.86 (0.62–1.01) | 0.82 (0.69–1.2) | 0.07 (−0.11–0.25) | 0.479 |
| Procalcitonin | 0.25 (0.14–1.08) | 0.22 (0.09–0.53) | −0.045 (−0.137–0.030) | 0.303 |
| Lactate dehydrogenase | 392 (325–557) | 384 (301–559) | −12 (−63.9–39) | 0.665 |
| Aspartate dehydrogenase | 49.5 (32.5–70.8) | 43.5 (29.8–74) | −7.7 (−15.000–13.0) | 0.995 |
| Alanine transaminase | 43 (29–75) | 41 (24.8–72.5) | −3.0 (−17.0–9.0) | 0.566 |
| Hospitalization | ||||
| Days from COVID-19 onset to hospital admission | 6 (4–7) | 7 (IQR 5–10) | −1.5 (−3.8–1.1) | 0.139 |
| Length of hospital stay, days | 35.5 (25–53) | 27 (17–37) | 10 (2.1–17.9) | 0.013 |
| Length of ICU stay | 27.5 (15–40) | 12 (7–24) | 12.8 (5.8–19.9) | 0.001 |
| % (n) | % (n) | Crude OR (95% CI) | ||
| Gender | ||||
| Male | 82 (49) | 69 (166) | 1.95 (0.96–3.98) | 0.060 |
| Female | 18 (11) | 31 (73) | ||
| Race | ||||
| Caucasian | 56.6 (34) | 50.2 (120) | ||
| Latin American | 13.3 (8) | 10.4 (25) | 0.88 (0.36–2.14) | 0.819 |
| Lifestyle habits | ||||
| Smoker | 3.3 (2) | 3.3 (8) | 0.97 (0.18–4.45) | 0.914 |
| Previous comorbidities | ||||
| Hypertension | 50 (30) | 38.4 (92) | 1.4 (0.81–2.6) | 0.203 |
| Diabetes mellitus | 21.6 (13) | 23 (55) | 0.82 (0.41–1.6) | 0.578 |
| Asthma | 0 (0) | 3.7 (9) | 0.79 (0.74–0.84) | 0.127 |
| COPD | 5 (3) | 3.7 (9) | 1.3 (0.35–5.1) | 0.712 |
| Ischemic heart disease | 3.3 (2) | 7.5 (18) | 0.42 (0.09–1.8) | 0.386 |
| Valvular heart disease | 1.6 (1) | 0.83 (2) | 2.0 (0.17–22.5) | 0.491 |
| Auricular fibrillation | 1.6 (1) | 3.3 (8) | 0.48 (0.06–3.9) | 0.693 |
| Obesity | 38.3 (23) | 35.1 (84) | 0.96 (0.53–1.75) | 0.911 |
| Class 1 | 25 (15) | 23 (55) | 0.95 (0.48–1.86) | 0.894 |
| Class 2 | 11.6 (7) | 7.9 (19) | 1.28 (0.50–3.32) | 0.598 |
| Class 3 | 1.6 (1) | 4.6 (11) | 0.31 (0.04–2.55) | 0.257 |
| Bleeding | 16.3 (8) | 3.8 (7) | 4.9 (1.7–14.5) | 0.004 |
| Transfusions | ||||
| Transfusion of blood components | 50 (30) | 25.5 (61) | 2.9 (1.62–5.23) | 0.000 |
| Platelet’s transfusion | 13.3 (8) | 5.4 (13) | 2.6 (1.05–6.78) | 0.032 |
| Fresh-frozen plasma transfusion | 8.3 (5) | 4.1 (10) | 2.0 (0.68–6.33) | 0.188 |
| ICU management | ||||
| Noninvasive mechanical ventilation | 60 (36) | 58.1 (139) | 1.09 (0.60–1.97) | 0.764 |
| Invasive mechanical ventilation | 88.3 (53) | 66.5 (159) | 3.8 (1.65–8.76) | 0.001 |
| Tracheotomy | 60 (36) | 43.9 (105) | 1.9 (1.06–3.38) | 0.028 |
| Prone positions | 81.6 (49) | 53.5 (128) | 3.8 (1.79–8.18) | 0.000 |
| Sepsis | 33.3 (20) | 17.9 (43) | 3.06 (1.46–6.39) | 0.002 |
| Deaths | 38.3 (23) | 26.7 (64) | 1.70 (0.93–3.07) | 0.078 |
* The cases of thrombosis were distributed as follows: 31 cases of deep vein thrombosis (DVT); 26 of pulmonary embolism (PE) (24 of them peripheric and 2 central PE); 3 cases of stroke. A total of 15 cases of PE and 1 case of stroke also presented DVT. Nine cases of DVT also presented catheter-related thrombosis. No cases of acute myocardial infarction were found in this sample.