Table 2.
Isoeleutherin analogues and their toxicity.
| Toxicity * | Protox | Mutagenicity * | Carcinogenicity * | Protox | HeRG * | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Algae | Daphnia | Minnow | Medaka | Cytotoxicity | Mutagenicity | Mouse | Rat | Carc. | |||
| CP1 | T | T | VT | VT | Toxic | NM | M (0) | + | + | - | LR |
| CP2 | T | T | VT | VT | Toxic | NM | M (0) | + | + | - | LR |
| CP3 | T | T | VT | VT | Toxic | NM | M (0) | + | + | - | LR |
| CP4 | T | T | VT | VT | Toxic | NM | M (1) | + | + | - | MR |
| CP5 | T | T | VT | VT | Toxic | NM | M (0) | + | + | - | LR |
| CP6 | T | T | VT | VT | Toxic | NM | M (1) | + | + | - | MR |
| CP7 | T | NT | VT | VT | Non-toxic | NM | M (1) | - | + | + | LR |
| CP8 | T | T | VT | VT | Toxic | NM | M (0) | + | + | - | MR |
| CP9 | T | T | VT | VT | Toxic | NM | M (0) | + | + | - | LR |
| CP10 | T | NT | VT | VT | Non-toxic | NM | M (1) | - | + | + | LR |
| CP11 | T | T | VT | VT | Non-toxic | NM | M (1) | - | + | + | LR |
| CP12 | T | T | VT | VT | Toxic | NM | M (0) | + | + | - | LR |
| CP13 | T | T | VT | VT | Non-toxic | NM | NM (0) | + | - | - | LR |
| CP14 | T | T | VT | VT | Toxic | NM | M (0) | + | + | - | LR |
| CP15 | T | NT | VT | VT | Non-toxic | NM | M (2) | - | + | + | LR |
| CP16 | T | NT | VT | VT | Non-toxic | NM | M (1) | - | + | + | LR |
| CP17 | T | T | VT | VT | Toxic | NM | M (0) | + | + | - | LR |
| CP18 | T | NT | VT | VT | Non-toxic | NM | M (2) | - | + | + | MR |
| CP19 | T | NT | VT | VT | Non-toxic | M | M (2) | - | + | - | MR |
| CP20 | T | T | VT | VT | Non-toxic | M | M (2) | - | - | + | MR |
| CP21 | T | NT | VT | VT | Non-toxic | M | M (2) | - | + | - | LR |
| CP22 | T | NT | VT | VT | Non-toxic | NM | M (2) | - | + | + | LR |
| ISO | T | T | VT | VT | Non-toxic | NM | M (1) | - | + | + | MR |
* Preadmet: Toxicity in algae (T-toxic < 1mg/mL and NT-non-toxic > 1 mg/mL) [19]; Daphnia sp (T-toxic < 0.22 µg/mL and NT-non-toxic > 0.22 µg/mL) [20], Medaka (VT-very toxic < 1 mg/L, T-toxic between 1–10 mg/L, harmful between 10–100 mg/L and NT-non-toxic > 100 mg/L) [21]; Minnow (VT—Very toxic < 1mg/L; T—Toxic 1–10 mg/L; ST—Slightly toxic 10–100 mg/L; Non-Toxic > 100mg/L) [19]; Carcinogenicity: C: Carcinogenic; NC: Non-carcinogenic and Mutagenicity: M: Mutagenic; NM: Non-Mutagenic; LR: low risk; MR: medium risk; M (0/1/2): number of Salmonella strains that were positive.