Table 2.

Structures of SARS-CoV-2 Omicron subvariant spikes. All the higher resolution structures of the free ectodomain trimer and its ACE-2 complexes that are available in the PDB are listed, as are the RBD orientations, spike conformational state (Figure 1), average MODA score of the 3 RBD modules, dipole moment (Debyes) of the S ectodomain (unless “n.a.” which indicates insufficient data), numbers of bound ACE-2 molecules, resolution (Å), PDB code, and reference.

Variant	RBDs	State	MODA	Dipole	Ligand	Resolution	PDB	Reference
BA.1	3 down	1.0	n.a.	9758	-	2.56	7wp9	[13]
BA.1	down	1.0	n.a.	7853	-	2.79	7t9j	[14]
BA.1	3 down	1.0	4836	10765	-	3.10	7wk2	[15]
BA.1	3 down	1.0	3520	11247	-	3.10	7tnw	[16]
BA.1	3 down	1.0	8660	9548	-	3.36	7tf8	[17]
BA.1	3 down	1.0	8676	9460	-	3.50	7tl1	[17]
BA.1	3 down	1.0	9198	11881	-	4.00	7wg7	[18]
BA.1	1 up	1.1	9510	11663	-	3.00	7y9s	[19]
BA.1	1 up	1.1	9244	11403	-	3.00	7tgw	[20]
BA.1	1 up	1.1	5382	12246	-	3.02	7qo7	[21]
BA.1	1 up	1.1	11654	6923	-	3.11	7thk	[22]
BA.1	1 up	1.1	9475	10391	-	3.29	7tb4	[23]
BA.1	1 up	1.1	5329	11097	-	3.40	7wk3	n.a.
BA.1	1 up	1.1	9587	12937	-	3.40	7wg6	[18]
BA.1	1 up	1.1	6242	11702	-	3.40	7to4	[16]
BA.1	1 up	1.1	n.a.	n.a.	-	3.40	7tei	[17]
BA.1	1 up	1.1	6237	11215	-	3.40	7wvn	[15]
BA.1	1 up	1.1	3911	9486	-	3.41	7wvo	[15]
BA.1	1 up	1.1	9654	10175	-	3.50	7tl9	[17]
BA.1	1 up	3.1	1885	4158	1 ACE-2	2.77	7wpa	[13]
BA.1	1 up	3.1	4368	4393	1 ACE-2	2.85	7y9z	[19]
BA.1	1 up	3.1	2440	2511	1 ACE-2	2.90	7ws9	[24]
BA.1	1 up	3.1	3085	3906	1 ACE-2	3.13	7xo5	[25]
BA.1	1 up	3.1	3423	4672	1 ACE-2	3.69	7wk4	[15]
BA.1	2 up	3.2	5248	5256	1 ACE-2	3.66	7wk5	[15]
BA.1	2 up	3.2	5261	5243	1 ACE-2	3.70	7wvp	[15]
BA.1	3 up	3.3	7420	5770	1 ACE-2	4.04	7wvq	[15]
BA.1	2 up	4.2	542	n.a.	2 ACE-2	2.45	7t9k	[14]
BA.1	2 up	4.2	1070	7679	2 ACE-2	3.00	7ws8	[24]
BA.1	2 up	4.2	953	4278	2 ACE-2	3.24	7xo4	[25]
BA.1	2 up	4.2	2523	9770	2 ACE-2	3.30	7xid	[25]
BA.1	2 up	4.2	2448	8324	2 ACE-2	3.40	7xch	[19]
BA.1	2 up	4.2	1663	8544	2 ACE-2	3.50	7wgb	[18]
BA.1	3 up	5.0	112	12925	3 ACE-2	3.10	7ya0	[19]
BA.2	3 down	1.0	7252	10081	-	3.25	7xix	[7]
BA.2	3 down	1.0	6356	10173	-	3.31	7ub0	[26]
BA.2	3 down	1.0	5908	9760	-	3.35	7ub5	[26]
BA.2	3 down	1.0	6739	10146	-	3.52	7ub6	[26]
BA.2	1 up	1.1	7481	11259	-	3.62	7xiw	[7]
BA.2	1 up	3.1	2537	3265	1 ACE-2	3.20	7xoa	[25]
BA.2	2 up	4.2	511	4683	2 ACE-2	3.30	7xob	[25]
BA.2	2 up	4.2	1011	7916	2 ACE-2	3.38	7xo7	[25]
BA.2	3 up	5.0	619	12139	3 ACE-2	3.48	7xo8	[25]
BA.2.12.1	3 down	1.0	7811	10381	-	3.48	7xns	[7]
BA.2.13	3 down	1.0	5230	10781	-	3.49	7xnr	[7]
BA.2.75	3 down	1.0	8214	8158	-	2.86	8gs6	[27]
BA.2.75	3 down	1.0	6241	9500	-	3.19	7yqu	[28]
BA.2.75	3 down	1.0	6732	9285	-	3.51	7yqw	[28]
BA.2.75	1 up	1.1	6246	9661	-	3.45	7yqt	[28]
BA.2.75	1 up	1.1	6202	9646	-	3.58	7yqv	[28]
BA.2.75	1 up	3.1	3649	6056	1 ACE-2	3.30	7yr2	[28]
BA.2.75	2 up	4.2	2693	10929	2 ACE-2	3.52	7yr3	[28]
BA.3	3 down	1.0	7674	10912	-	3.07	7xiy	[7]
BA.4/5	3 down	1.0	6715	10753	-	3.52	7xnq	[7]