Table 2.
Compds | R | Inhibition Rate a (%) | |
---|---|---|---|
AChE | BChE | ||
2b | o-F | N.A. b | 49.0 |
2f | m-Cl | N.A. | 3.4 |
2j | p-Br | N.A. | 34.5 |
2l | m-CF3 | N.A. | 49.1 |
2q | m-CH3 | N.A. | 8.7 |
2s | o-OCH3 | N.A. | 39.6 |
2t | m-OCH3 | N.A. | 55.0 |
2u | p-OCH3 | N.A. | 40.7 |
2w | 3,4-(OCH3)2 | N.A. | 9.4 |
2z | 3,4-Cl2 | N.A. | 12.1 |
2ab | 2,6-F2 | N.A. | 24.9 |
2ac | p-CN | N.A. | 17.7 |
donepezil | - | 62.7 | - c |
tacolin | - | - | 98.2 |
a Compounds concentration 100 µM; b N.A.—not active; c—not test.