Table 3.

Discrimination and reclassification of adding Big ET-1 to the model for LVRR.

	Model 1 (Basic Model)	Model 2 (Basic Model + Big ET-1)	p-Value
AUC	0.684 (0.624–0.744)	0.721 (0.663–0.779)	0.042
IDI	reference	0.033 (0.012,0.054)	0.002
cNRI	reference	0.354 (0.1253–0.583)	0.002

The basic prediction model constructed using stepwise regression [including BMI, SBP, diagnosis of T2DM and the treatment with ACEI/ARB]. cNRI and IDI of the additional value of Big ET-1 was calculated at 5 years of follow-up. The level of Big ET-1 was log2 transformed.