Figure 3.

The molecular architecture of the I_SOC in vascular endothelial cells. (A), the endothelial I_SOC is mediated by a complex ion channel signalplex that is located on plasmalemmal caveolae. The ion channel pore is contributed by TRPC1 and TRPC4 channels, which are informed about changes in [Ca²⁺]_ER by STIM1. The signalling microdomain is enriched with InsP₃Rs, which interact with the TRPC1 and TRPC4 subunits via caveolin-1. For sake of clarity, only the interaction between InsP₃Rs and TRPC1 has been shown. The monomeric GTP−binding protein, RhoA, also supports the interaction between InsP₃Rs and TRPC1 via F−actin polymerization (two bundles of F-actin were drawn beneath the plasma membrane). (B), the IV relationship of the endothelial I_SOC.