Table 2.

Electrophysiological features of the endothelial I_CRAC.

Endothelial Cell Type	ICRAC: Electrophysiological and Pharmacological Features	Agonist Used to Reduce the [Ca2+]ER	Intracellular Ca2+ Buffering	Reference
CPAE cells	IR, Erev > +40 mV, depotentiation of the Na+ currents under DVF conditions, inhibited by 10 µM La3+	Intracellular InsP3	12 mM BAPTA	[35]
HUVECs, hPAECs	IR, Erev > +40 mV, depotentiation of the Na+ currents under DVF conditions, inhibited by 10 µM Gd3+, activated by 5 µM 2-APB	Intracellular dialysis with BAPTA or extracellular thapsigargin	20 mM BAPTA or [Ca2+]i buffered at 98 nm/L for thapsigargin-evoked currents	[38]

Abbreviations: 2-APB: 2-Aminoethoxydiphenyl borate; CPAE cells: calf pulmonary artery endothelial cells; DVF: divalent-free; IR: inward rectification; E_rev: reversal potential; hPAECs: human pulmonary artery endothelial cells; HUVECs: human umbilical vein endothelial cells.