Table 3.

Endothelial functions modulated by the I_CRAC.

Endothelial Cell Type	Evidence of ICRAC Involvement	Function	Reference
Ea.hy926	Orai1DN	ER Ca2+ refilling	[154]
HUVECs	siSTIM1 and siOrai1, OraiDN, Synta66, BTP-2, GSK	Proliferation, cell cycle control (S and G2/M phase), tube formation	[38,39,143]
HUVECs	siSTIM1, STIM1over, BTP-2	Migration	[60]
Rat aortic endothelial cells	10–100 µM GSK (IC50 = 34.22 µM)	Aorta sprouting	[143]
Mouse retinal vasculature	2.6–31.8 mg/kg GSK (IC50 = 18.4 mg/kg)	Neovessel formation	[143]
Porcine aortic endothelial cells	siSTIM1	NO release	[160]
Endothelial cells from mesenteric resistance and thoracic arteries	STIM1EC-/- mice	NO release and vasorelaxation	[161,162]
Mouse cerebrovascular endothelial cells	20 µM BTP-2, 10 µM La3+	NO release	[175]
Human cerebrovascular endothelial cells	10 µM Pyr6	NO release	[62,169]

Abbreviations: Orai1^DN: expression of dominant negative Orai1; siOrai1: small interfering RNA selectively targeting Orai1; siSTIM1: small interfering RNA selectively targeting STIM1; STIM1^EC-/- mice: endothelial cell-specific knockout mice; STIM1^over: STIM1 overexpression.