Table 5.

Electrophysiological features of the endothelial I_SOC.

Endothelial Cell Type	ISOC: Electrophysiological and Pharmacological Features	Agonist Used to Reduce the [Ca2+]ER	Intracellular Ca2+ Buffering	Reference
hPAECs	Slightly DR, Erev ≈ 0 mV, inhibited by 1 µM La3+	CPA	1.15 mM EGTA, no CaCl2	[192]
CPAE cells	Linear IV, Erev ≈ 0 mV, permeability to Na+, K+, Ca2+, inhibited by 50 µM La3+	CPA	0.3 mM CaCl2, 2.2 mM EGTA	[187]
HUVECs	Single-channel conductance: 28 pS (140 mM KCl in the bath and the pipette)	CPA	Cell-attached single channel study	[190]
HUVECs	Linear IV, Erev ≈ 0 mV, permeability to Na+, K+, Ca2+, inhibited by 50 µM La3+	Intracellular infusion of InsP3	10 mM BAPTA, no CaCl2	[37,188]
HUVECs	Linear IV, Erev ≈ 0 mV, inhibited by 1 µM La3+	Intracellular infusion of 3-deoxy-3-fluoro-D-myo-InsP3 (metabolism-resistant InsP3) and/or thapsigargin	12 mM BAPTA, no CaCl2	[43,193]

Abbreviations: CPAE cells: calf pulmonary artery endothelial cells; HUVECs: human umbilical vein endothelial cells.