Table 6.
Endothelial functions modulated by the ISOC.
| Endothelial Cell Type | Evidence of ISOC Involvement | Function | Reference |
|---|---|---|---|
| HUVECs, HMECs | TRPC1over, anti-TRPC1 antibody, 1 µM La3+ | VEGF-induced increase in endothelial permeability | [193] |
| HUVECs | siTRPC1 | Angiotensin II-induced increase in endothelial permeability | [206] |
| HUVECs | siTRPC1 | Thrombin-induced apoptosis | [194] |
| HUVECs | siTRPC1, TRPC1over | Ca2+- and TNFα-induced VCAM-1 upregulation and monocyte adhesion | [219] |
| hPAECs | TRPC1over | Thrombin-induced increase in endothelial permeability | [201] |
| hPAECs, mPAECs | siTRPC1, TRPC4-/- mice | Nuclear translocation of NF-κB | [207] |
| Zebrafish | TRPC1-/- | Vascular development | [212] |
| HUVECs | siTRPC1, siTRPC4 | Proliferation and tube formation | [38,217] |
| HRMECs | siTRPC4 | VEGF-induced migration and tube formation | [216] |
| MAECs | siTRPC1 | VEGF-induced Ca2+ entry | [213] |
| MCAECs | TRPC1-/- mouse | Migration and tube formation in vitro and neovessel formation in vivo | [215] |
Abbreviations: HMECs: human dermal microvascular endothelial cells; hPAECs: human pulmonary artery endothelial cells; HRMECs: human retinal microvascular endothelial cells; MAECs: mouse aortic endothelial cells; MCAECs: mouse coronary artery endothelial cells; mPAECs: mouse pulmonary artery endothelial cells; HUVECs: human umbilical vein endothelial cells; siTRPC1: small interfering RNA selectively targeting TRPC1; TRPC1over: TRPC1 overexpression.