. 2023 Feb 7;24(4):3259. doi: 10.3390/ijms24043259

Table 7.

Electrophysiological features of the endothelial I_CRAC-like current.

Endothelial Cell Type	I_SOC: Electrophysiological and Pharmacological Features	Agonist Used to Reduce the [Ca²⁺]_ER	Intracellular Ca²⁺ Buffering	Reference
BAECs	IR, E_rev ≈ +6 mV, permeable to Na⁺, Ca²⁺ and Ba²⁺, P_Ca/P_Na > 10, single-channel conductance: 5 pS (symmetrical Na₂SO₄), inhibited by 200 µM La³⁺	tBHQ	2 mM CaCl₂, 5 mM BAPTA	[44,189]
rPAECs	Slight IR, E_rev ≈ +30/+40 mV, anomalous mole fraction behaviour, inhibited by 50 µM La³⁺	Extracellular application of thapsigargin	[Ca²⁺]_i buffered at 100 nm/L	[51,69,86,140,220,221]
MAECs	IR, E_rev ≈ +40 mV, Na⁺ permeability anomalous mole fraction behaviour, P_Ca/P_Na ≈ 160, inhibited by 1 µM La³⁺	Intracellular dialysis of InsP₃ and extracellular application of tBHQ	12 mM BAPTA	[87]
EA.hy926	IR, Er_ev ≈ −7 mV, anomalous mole fraction behaviour, Ca²⁺-dependent inactivation, inhibited by 10 µM La³⁺	Extracellular application of thapsigargin	No CaCl₂, no BAPTA/EGTA	[46]

Abbreviations: BAECs: bovine aortic endothelial cells; IR: inward rectification; MAECs: mouse aortic endothelial cells; P_Ca/P_Na: Ca²⁺/Na⁺ permeability ratio; rPAECs: rat pulmonary artery endothelial cells.