Figure 2.
Domains of the gammaretroviral envelope glycoprotein. (a) Linear depiction of a gammaretrovirus Env highlighting conserved features. S–S indicates a disulfide bond between the CXXC and C(X)6CC motifs. HR1 and HR2 are the two heptad repeat domains of the transmembrane subunit. HR1 overlaps slightly with the immunosuppressive domain (ISD). (b left) Schematic of an envelope glycoprotein trimer, composed of three heterodimers comprising SU and TM subunits. (b right) Depiction of an Env monomer, highlighting predicted locations of conserved regions including the ISD, HR1 and HR2, the fusion peptide and cytoplasmic tail domains. SU is linked to TM through a disulfide bond, depicted here by a pink line.