Table 1.

Comparison of different capture probes for the analysis of siRNA-01 QCs in monkey plasma.

PNA Probe 75 pmols/Sample	LLOQ QC 2.00 ng/mL	Low QC 6.00 ng/mL	Mid QC 500 ng/mL	High QC 750 ng/mL
Measured Conc.	2.14	5.78	502.18	758.45
	2.03	6.32	417.41	726.41
	1.79	6.21	446.34	726.46
	1.95	6.00	472.78	788.82
Mean	1.98	6.08	459.68	750.03
S.D.	0.15	0.24	36.25	29.94
N	4	4	4	4
% CV	7.5	4.0	7.9	4.0
% Nominal	98.7	101.3	91.9	100.0
PNA and DNA Probes 37.5 pmols Each/Sample	LLOQ QC 2.00 ng/mL	Low QC 6.00 ng/mL	Mid QC 500 ng/mL	High QC 750 ng/mL
Measured Conc.	1.98	6.25	526.62	751.12
	2.09	6.07	457.77	745.37
	2.24	6.04	533.94	752.48
	2.01	6.42	456.61	742.90
Mean	2.08	6.19	493.73	747.97
S.D.	0.12	0.18	42.31	4.57
N	4	4	4	4
% CV	5.6	2.8	8.6	0.6
% Nominal	103.9	103.2	98.7	99.7