Table 4.

Matrix effect of the analysis of siRNA-01 in monkey plasma.

	Low QC (6.00 ng/mL)			High QC (750 ng/mL)
	Analyte Matrix Factor	IS Matrix Factor	IS-Normalized Matrix Factor	Analyte Matrix Factor	IS Matrix Factor	IS-Normalized Matrix Factor
Lot 1	0.92	0.97	0.95	1.00	1.01	0.99
	0.95	1.02	0.93	0.98	0.98	1.00
	1.01	1.01	1.00	0.94	0.95	0.99
Lot 2	0.92	1.00	0.92	1.04	1.02	1.02
	0.97	1.00	0.97	0.95	0.92	1.03
	0.99	0.96	1.03	1.08	1.00	1.08
Lot 3	1.02	1.01	1.01	0.99	0.98	1.01
	0.98	1.03	0.95	0.98	1.00	0.98
	0.94	1.01	0.93	1.04	0.96	1.08
Mean			0.97			1.02
S.D.			0.040			0.040
n			9			9
% C.V.			4.1			3.9