Figure 8.

NOX2 deletion prevents IL-17A-induced neurovascular coupling impairment. CBF in response to whiskers stimulations measured in vivo by laser Doppler flowmetry in C57BL/6 WT or NOX2^−/− male mice receiving IL-17A Rb through an osmotic minipump (50 pg/kg/h, 7 days). The graphs depict (A) CBF as percentage changes with respect to the initial CBF value, (B) resting CBF value as LDU, and (C,D) 1 s average curves of the evoked CBF, expressed in arbitrary unit. SEM is represented by the lighter tone shade surrounding each curve. Data were analyzed using an ANOVA for factorial design followed by a Bonferroni post-test. * p < 0.05; n = 7–9 per group.