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. 2023 Feb 15;24(4):3910. doi: 10.3390/ijms24043910

Table 2.

Summary of the results of the studies included in the systematic review on the role of microRNA in breast cancer diagnosis.

First Author, Year Specimen Source MiR Direction Cut_Off
(ng/mL)		 AUC Sens Spec Fold Change
Zhu W, 2009 [13] Serum 16 Up
145 Up
155 Down
Heneghan H, 2010 [14] Blood 21 Up
145 Up
155 Up
195 Up 0.94
(0.91–0.97)		 87.70 91.00 25.00
10b Down
Let-7a Up
Roth C, 2010 [15] Serum 141
155 Up 1.60
10b
34a
Wang F, 2010 [16] Serum 21 Up 2.50
126 Down 2.00
155 Up 3.50
335 Up 2.00
106a Up 1.90
199a Down 2.00
Asaga S, 2011 [17] Serum 21 Up 3.30 0.72 75.00 67.00
Guo LJ, 2012 [18] Serum 181a Down 0.74 0.67
(0.60–0.74)		 70.70 59.90 0.36
Schrauder MG, 2012 [19] Serum 202 Up 0.68 19.38
718 Down 0.77 5.44
Schwarzenbach H, 2012 [20] Serum 21 0.85
(0.78–0.91)
214 0.92
(0.88–0.97)
19a
20a 0.68
(0.59–0.77)
Sun Y, 2012 [21] Serum 155 Up 1.91 0.80
(0.65–0.82)		 65.00 81.80 2.94
van Schooneveld E, 2012 [22] Serum 215 Up
299 Down
411 Down
452 Down
Wu Q, 2012 [23] Serum 222 Up 0.01 0.67
(0.57–0.78)		 74.00 60.00
Zhao FL, 2012 [24] Serum 10b Up
Chan M, 2013 [25] Serum 1 Up 2.67
133a Up 2.62
133b Up 2.41
92a Up 1.32
Cuk K, 2013 [26] Plasma 409 Up 0.66
(0.59–0.74)
801 Up 0.64
(0.56–0.72)
148b Up 0.65
(0.58–0.73)
376c Up 0.66
(0.59–0.74)
Eichelser C, 2013 [27] Serum 17 Down 0.68 18.80 100.00
93 Up 0.70 44.90 100.00
155 Up 0.78 70.60 42.70
373 Up 0.88 76.60 100.00
10b Up 21.80 92.10
34a Up 0.64 59.80 76.00
Godfrey AC, 2013 [28] Serum 222 Down
181a Up
18a Up
Kumar S, 2013 [29] Plasma 21 Up
146a Up
Ng EKO, 2013 [30] Plasma 16 Up 0.91
(0.87–0.95)
21 Up 0.81
(0.74–0.88)
145 Down 0.63
(0.52–0.74)
451 Up 0.94
(0.91–1.00)
Si H, 2013 [31] Serum 21 Up 0.93
(0.89–0.92)
92a Down 0.92
(0.87–0.97)
Wang PY, 2013 [32] Serum 182 Up
Zeng RC, 2013 [33] Plasma 30a Down 0.01 0.76
(0.68–0.83)		 74.00 65.60
Eichelser C, 2014 [34] Serum 101 Up
372 Up
373 Up
Hamdi K, 2014 [35] Serum 24 Down
320 Down
335 Down
337 Down
451 Down 15.80
486 Down
548 Down
15a Down
29a Down
30b Down
342-3p Down
342-5p Down
Joosse SA, 2014 [36] Serum 202 Up
Let-7b Up
Kodahl AR, 2014 [37] Serum 107 0.66
139 1.44
143 1.65
145 1.56
365 1.88
425 0.84
133a 1.68
15a 1.84
18a 0.65
Mar-Aguilar F, 2014 [38] Serum 21 6.48 0.95
(0.91–0.99)		 94.40 80.00
145 15.93 0.98
(0.95–1.00)		 94.40 100.00
155 7.92 0.99
(0.99–1.00)		 94.40 100.00
191 4.85 0.79
(0.71–0.88)		 72.20 90.00
382 0.97
(0.94–1.00)		 94.40 90.00
10b 59.22 0.95
(0.91–0.99)		 83.30 100.00
125b 8.46 0.95
(0.91–0.99)		 88.90 80.00
McDermott AM, 2014 [39] Serum 223 Down
652 Down
181a Down
29a Down
Shen J, 2014 [40] Plasma 409
133a 8.30
148b 5.10
Sochor M, 2014 [41] Serum 24 Up
155 Up
181b Up
19a Up
Zearo S, 2014 [42] Serum 484 1.60
Zhao FL, 2014 [43] Serum 195 Down 0.50 0.86
(0.82–0.90)		 69.00 89.20 2.38
Antolin S, 2015 [44] Blood, serum and plasma 141
200c Down 0.79 90.00 70.20
Li XX, 2015 [45] Serum Let-7c Down 0.85
(0.79–0.91)		 87.50 78.90
Mangolini A (A), 2015 [46] Serum 145 Down
425 Down
652 Down 0.83
(0.73–0.93)
10b Up
148b Down 0.74
(0.62–0.86)
Mangolini A (B), 2015 [46] Serum 145 Down
425 Down
652 Down 0.69
(0.58–0.80)
10b Up
148b Down 0.66
(0.51–0.80)
Matamala N, 2015 [47] Plasma 21 Up 0.61
(0.53–0.68)
96 Up 0.72
(0.65–0.78)		 73.00 66.00
505 Up 0.72
(0.66–0.79)		 75.00 60.00
125b Up 0.64
(0.56–0.71)
Shaker O, 2015 [48] Serum 155 Up 39.57 0.99
(0.99–1.00)		 94.10 100.00 39.57
197 Up 29.80 0.98
(0.95–1.00)		 95.30 100.00 29.80
205 Up 27.48 0.99
(0.98–1.00)		 98.80 100.00 27.48
29b Up 41.94 0.99
(0.98–1.00)		 98.80 100.00 41.94
Zhang L, 2015 [49] Serum 424 Up 0.75
(0.67–0.84)		 1.77
199a Up 0.92
(0.87–0.96)		 2.65
29c Up 0.72
(0.64–0.81)		 1.97
Frères P, 2016 [50] Plasma 16 1.70
22 1.00
103 0.80
107 0.80
148a 1.40
19b 1.20
Let-7d 0.90
Let-7i 0.70
Fu L, 2016 [51] Serum 184 Down 0.48 0.74
(0.66–0.82)		 87.50 71.00
382 Up 1.32 0.90
(0.85–0.96)		 93.00 75.00
598 Down 1.61 0.74
(0.66–0.82)		 52.00 92.50
1246 Up 0.55 0.94
(0.90–0.98)		 95.00 85.00
Hamam R, 2016 [52] Serum and Plasma 188 Up
1202 Up
1207 Up
1225 Up
1290 Up
3141 Up
4270 Up
4281 Up
642b Up
Hannafon BN, 2016 [53] Plasma 21 Up 0.69
(0.49–0.89)
122 Up
1246 Up 0.69
(0.50–0.88)
Let-7a Up
Motawi TM, 2016 [54] Serum 21 1.14 0.98
(0.96–1.00)		 96.00 94.00 2.20
221 1.21 0.97
(0.94–1.00)		 92.00 88.00 2.09
Shimomura A, 2016 [55] Serum 1246 88.30 93.40
1307 100.00 53.10
4634 3.40 73.60
6861 99.80 79.40
6875 14.70 76.80
Thakur S, 2016 [56] Serum 21 Up 0.79
(0.71–0.86)		 88.00 65.00
145 Down 0.73
(0.66–0.81)		 74.00 56.00
195 Down 0.80
(0.74–0.87)		 77.00 71.00
210 0.64
(0.55–0.72)		 78.00 61.00
221 0.63
(0.54–0.71)		 65.00 57.00
Let-7a 0.76
(0.69–0.83)		 71.00 67.00
Gao S, 2017 [57] Plasma 155 Up 0.77
(0.68–0.86)
Zhang K, 2017 [58] Blood 96 Up 2.73 0.77 53.00 100.00
182 Up 1.01 0.76 53.00 92.00
942 Up 1.04 0.81 67.00 100.00
30b Up 2.04 0.93 80.00 100.00
374b Up 1.52 0.82 87.00 69.00
Heydari N, 2018 [59] Serum 140 Up 0.13 0.67
(0.55–0.79)		 70.00 50.00
Zaleski M, 2018 [60] Plasma 21 0.58
(0.46–0.71)
92 0.46
(0.33–0.60)
155 0.53
(0.36–0.69)
222 0.53
(0.40–0.67)
34a 0.72
(0.61–0.84)
Let-7c 0.51
(0.38–0.64)
Kaharam M, 2019 [61] Blood 101-3p
126-3p
126-5p
144-3p
144-5p
301a
664b
McAnena P, 2019 [62] Blood 195 0.73
331 2.94
181a 1.19
Peña-Cano MI, 2019 [63] Serum 17 Up 0.50
195 Up 0.04 0.88
(0.78–0.98)		 83.30 78.30 4.33
221 Down 0.70
Raheem AR, 2019 [64] Serum 34a Down 5.05 0.67
(0.53–0.81)		 60.00 63.00
Soleimanpour E, 2019 [65] Plasma 21 Up 0.92
155 Up 0.99
Anwar SL, 2020 [66] Plasma 155 Up
Arabkari V, 2020 [67] Blood 16 Up 0.61
(0.47–0.76)
21 Up 0.65
(0.51–0.79)		 1.35
145 Up 0.83
(0.72–0.94)		 1.61
155 Up 0.76
(0.66–0.89)		 1.63
195 Down 0.81
(0.69–0.92)		 0.14
486 Up 0.90
(0.81–0.97)		 2.25
181a 1.52
451a Up 0.73
(0.61–0.86)		 1.62
Ashirbekov Y, 2020 [68] Plasma 16 0.69
21 1.35
29 0.98
145 2.36
191 1.87
210 0.69
222 0.98
Guo H, 2020 [69] Plasma 21 0.66
(0.53–0.78)
1273g 0.63
(0.51–0.76)
Holubekova V, 2020 [70] Plasma 484 Up 1.10
1260a Up 1.22
130a Up 1.20
99a Up 1.33
Hosseini Mojahed FH, 2020 [71] Serum 155 Up 1.40 0.89 77.80 88.89 1.00
Ibrahim AM, 2020 [72] Plasma 21 4.94 0.78 63.30 100.00
145 0.78 0.70 45.00 83.30
10b 2.52 0.73 53.30 100.00
181a 1.51 0.70 50.00 80.00
Let-7 0.52 0.72 50.00 93.30
Jang JY, 2020 [73] Plasma 21 Down 0.92
24 Down 0.96 65.00 96.00
202 Down 0.86
206 Down 0.94 79.00 96.00
223 Down 0.81
373 Down 0.96
1246 Down 0.93 53.00 95.00
6875 Down 0.96 86.00 96.00
219b Down 0.88
Kim J, 2020 [74] Plasma 202 Up 2.10 0.95
(0.88–1.02)		 90.00 93.30 9.60
Pastor-Navarro B, 2020 [75] Serum 21 0.77
(0.68–0.87)
155 0.32
(0.68–0.87)
205 0.65
(0.68–0.87)
Bakr NM, 2021 [76] Blood 373 360.00 0.98
(0.95–0.99)		 90.80 98.40
Diansyah MN, 2021 [77] Plasma 21 1.66 0.92
(0.83–1)		 92.30 81.20 4.36
Itani MM, 2021 [78] Plasma 21 Up 4.46 0.76
(0.64–0.88)		 73.00 81.00
139 Up 11.69 0.74
(0.62–0.87)		 78.00 75.00
145 Up 10.18 0.78
(0.66–0.90)		 83.00 78.00
155 Up 8.54 0.83
(0.71–0.95)		 76.00 96.00
425 Up 9.09 0.81
(0.69–0.93)		 78.00 91.00
451 Down 10.54 0.70
(0.57–0.83)		 78.00 75.00
130a Up 7.96 0.83
(0.72–0.94)		 70.00 100.00
23a Up 2.50 0.73
(0.61–0.85)		 73.00 72.00
Mohmmed EA, 2021 [79] Serum and Plasma 106a Up 0.95 83.00 100.00 3.63
Nashtahosseini Z, 2021 [80] Serum 210 Up 0.82 0.72
(0.60–0.83)		 68.00 51.00 2.72
660 Up 0.77 0.77
(0.66–0.88)		 79.00 61.00 2.71
Zhang K, 2021 [81] Blood 185 Up 1.08 0.91
(0.83–0.99)		 91.18 76.92 4.00
362 Up 1.53 0.93
(0.88–0.99)		 83.82 100.00 2.97
106b Up 1.26 0.82
(0.68–0.95)		 79.41 76.92 1.89
142-3p Up 6.87 0.85
(0.76–0.98)		 97.06 61.54 3.18
142-5p Up 1.60 0.85
(0.71–0.99)		 85.29 76.92 2.46
26b Up 1.34 0.89
(0.81–0.97)		 83.82 84.62 3.32
Zhao T, 2021 [82] Serum 25 Up 0.75
(0.66–0.84)		 57.10 95.00
Li X, 2022 [83] Serum 9 Up
17
148a Up
Liu H, 2022 [84] Serum 103a Up 3.40 0.70
(0.62–0.78)		 78.20 74.70
Mohamed AA, 2022 [85] Serum 155 Up 7.50 0.94
(0.89–0.98)		 86.90 90.00
373 Up 10.00 0.95
(0.90–0.98)		 85.00 100.00
10b Up 9.50 0.77
(0.69–0.84)		 60.00 93.00
34a Down 10.50 0.89
(0.82–0.94)		 91.00 75.00
Zavesky L, 2022 [86] Plasma 451a Down 1.39
548b Up 3.60
Zou R, 2022 [87] Serum 24 Up 0.76 0.62
324 Down 0.52 0.31
377 Down 0.73 0.67
497 Up 0.56 0.15
125b Up 0.58 0.13
133a Up 0.63 0.41
19b Down 0.63 0.26
374c Down 0.71 0.99