Figure 3.

Anti-inflammatory mechanism of EGT on AP-1 and MAPKs signaling pathway. Under the induction of environmental pressure, UV or oxidative damage, ROS can easily attack the nucleus and produce a large number of inflammatory cytokines, then activate the NF-κB cascade signaling pathways. Therefore, the nucleus began to express OCTN-1 in large quantities to promote more EGT transport into cells to play a role. While clearing ROS, EGT inhibited the production of activated AP-1 and MAPKs cascade signaling pathways to relieve inflammation.