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. 2023 Feb 8;28(4):1648. doi: 10.3390/molecules28041648

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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EGT potentially regulates RUNX1 via the protective skin barrier. Additionally, EGT can potentially downregulate the inflammatory factor IL-33 induced by MAPK kinase, reduce the production of inflammatory markers (loricrin, keratin 1, and keratin 10), and indirectly regulate apoptosis caused by p53/63 by inhibiting the excessive increase in ROS. Interestingly, EGT and RUNX1 protein expression induce a strong binding energy related to the proliferation and differentiation of keratinocytes or skin stem cells, and ultimately promote the renewal of skin barrier function.