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Looekeyolide biosynthetic gene clusters among nine Roseofilum metagenome-assembled genomes from this study and previously published works. Natural products have not been characterized from two Pacific Roseofilum strains (Cya2, AO1). Looekeyolides A/B have been detected from both Caribbean and Pacific strains (Guam_bin12, BLZ4_bin2, BLZD4_bin1). Looekyolides C/D have only been detected in Caribbean Roseofilum from S. siderea corals (SID1.26, SID2.16, SID3.16, SBFL.6).
