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. 2023 Jan 24;21(2):80. doi: 10.3390/md21020080

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of diHEP-DPA and 5-FU on the infiltration of M2-like TAMs and the NF-κB signaling pathway. Relative mRNA levels of TAMs secretions including (A) MMP2, (B) MMP9, (C) VEGF, (D) IL-6, and (E) TNF-α in isolated tumors. Relative mRNA levels of (F) CD206 were determined via qRT-PCR. (G) The protein levels of CD206, p65, and pp65 were detected by western blotting in isolated tumors. The relative levels of (H) CD206 and (I) pp65/p65 were calculated using ImageJ. Data are expressed as mean ± SD; n = 3 per group. * p < 0.05 compared with the control group; ^# p < 0.05 compared with the 5-FU group.