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. 2023 Jan 30;15(2):455. doi: 10.3390/pharmaceutics15020455

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Repeated UMBO is associated with microglia’s gene signature in the GL261 mouse model. (Panel A): UMBO did not influence antigen presentation gene signature compared to the non-treated. (Panel C): UMBO alone is associated with a significant (** p < 0.01) enrichment of microglia sensome gene signature (Panel D) compared to vehicle (n = 3). No significant difference was observed in microglial gene expression (Panel B). Heat maps of microglia gene signature and antigen presentation genes used in panels A and C are presented in Supplementary Material, Figure S5. (Panel D,E) represent the ddPCR analysis of Luciferase DNA (Panel D) and mKate2 DNA (Panel E) in the blood 30 min following UMBO.